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目的:探讨社区应用中效胰岛素睡前注射联合口服降糖药物治疗2型糖尿病患者的有效性和安全性。方法:选择2010年1月至2011年1月经口服降糖药疗效不佳的102例2型糖尿病患者作为研究对象,每晚睡前注射中效胰岛素精蛋白生物合成人胰岛素注射液N,并联合应用口服降糖药物,治疗前,治疗后6、12个月检测空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇等指标。结果:经过联合治疗12个月后,患者空腹血糖由治疗前的(11.41±2.10)mmol/L下降到(6.92±0.47)mmol/L;餐后2 h血糖由(13.31±1.80)mmol/L下降到(9.48±1.22)mmol/L;糖化血红蛋白由(8.88±1.78)%下降到(6.89±0.54)%(P<0.05)。结论:在社区适时应用睡前中效胰岛素联合口服降糖药物治疗2型糖尿病安全有效,可以有效降低血糖、糖化血红蛋白,改善血脂。
Objective: To investigate the efficacy and safety of community-based insulin in patients with type 2 diabetes treated with bedtime injection combined with oral hypoglycemic agents. Methods: From January 2010 to January 2011, 102 patients with type 2 diabetes mellitus who did not respond well to oral hypoglycemic agents were enrolled in this study. The patients were injected with insulin-producing human insulin injection N Application of oral hypoglycemic agents, before treatment, 6,12 months after treatment fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin, total cholesterol and other indicators. Results: After 12 months of treatment, fasting blood glucose decreased from (11.41 ± 2.10) mmol / L to (6.92 ± 0.47) mmol / L before treatment and (13.31 ± 1.80) mmol / L (9.48 ± 1.22) mmol / L and HbA1c decreased from (8.88 ± 1.78)% to (6.89 ± 0.54)% (P <0.05). Conclusion: It is safe and effective to use type 2 insulin in combination with oral hypoglycemic drugs before bedtime to treat type 2 diabetes mellitus. It can effectively lower blood glucose, glycosylated hemoglobin and improve blood lipid.