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血管平滑肌表型转化是高血压、动脉粥样硬化(AS)、血管成形术后再狭窄(RS)等疾病中血管平滑肌增殖和迁移的关键性起始步骤。本文对血管平滑肌表型转化及其影响、调控因素作了综述,以期为深入理解血管平滑肌表型转化机制和相关影响调控因素的研究提供理论基础,进而为相关疾病的综合诊治方法提供思路。
Phenotypic modulation of vascular smooth muscle is a key initial step in the proliferation and migration of vascular smooth muscle in diseases such as hypertension, atherosclerosis (AS), and restenosis after angioplasty (RS). This review summarizes the phenotypic changes of vascular smooth muscle and their regulatory factors. The purpose of this review is to provide a theoretical basis for further understanding of the phenotypic transformation mechanism of vascular smooth muscle and the related regulatory factors, and to provide ideas for the comprehensive diagnosis and treatment of related diseases.