僵人综合征又称全身肌强直综合征,是一组少见的、进行性、病程波动的肌强直和肌痉挛。多见于男性。临床表现为对称性的骨骼肌僵硬、抽搐、痛性肌痉挛等。现将2例报告如下。例1,男,31岁。患者在劳动后感觉四肢麻木,双手抬举困难,逐渐加重,继之张口困难,不能进食,全身肌肉痉挛僵硬,语言不流利,行动困难,恐惧出汗,卧床不起,这种全身肌肉痉挛可被噪音,突然运动,情绪改变甚至微小的原因如谈话,咀嚼等诱发,反复活动可使症状减轻。体检:四肢肌肉均呈痉挛僵硬状态,吐字困难,表情苦丧,扣击任何部位的肌肉可导致全身肌肉痉挛发作及局部出现肌球。实验室检查:24小时尿肌酸测定36604,8μmol/ Stiff human syndrome, also known as myasthenia gravis syndrome, is a rare, progressive, fluctuating course of myotonia and muscle spasms. More common in men. Symptomatic clinical manifestations of skeletal muscle stiffness, convulsions, painful muscle spasms. Now report 2 cases as follows. Example 1, male, 31 years old. Patients feel limb numbness after work, both hands lift difficulties, and gradually increased, followed by mouth difficulties, can not eat, the whole body muscle spasm stiffness, the language is not fluent, difficult to move, fear of sweating, bedridden, this body muscle spasm can be Noise, sudden exercise, emotional changes and even minor causes such as talking, chewing and other induced, repeated activities can reduce the symptoms. Physical examination: limbs and muscles were spasm stiffness state, articulation difficulties, expressions of miserable, buckling any part of the muscle can cause systemic muscle spasms and partial onset of muscle myopathy. Laboratory tests: 24 hours urine creatine determination 36604, 8μmol /