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目的:探讨对不同分期的蕈样肉芽肿患者使用窄谱中波紫外线进行治疗的效果。方法 :对2010年1月~2014年12月期间我院收治的30例不同分期的蕈样肉芽肿患者的临床资料进行回顾性分析。我院将蕈样肉芽肿ⅠA期、ⅠB期、ⅡA期的患者归类为早期患者,将蕈样肉芽肿ⅡB期~ⅢB的患者归类为晚期患者。我院对这30例不同分期的蕈样肉芽肿患者均使用窄谱中波紫外线进行治疗,然后比较其治疗的效果。结果 :治疗结束后,蕈样肉芽肿早期患者治疗的总有效率为100%,蕈样肉芽肿晚期患者治疗的总有效率为61%。蕈样肉芽肿早期患者治疗的总有效率明显高于蕈样肉芽肿晚期患者,差异显著(P<0.05),具有统计学意义。蕈样肉芽肿早期患者平均的治疗次数及照射的剂量明显优于蕈样肉芽肿晚期患者,差异显著(P<0.05),具有统计学意义。蕈样肉芽肿早期患者病情的复发率为8.33%,蕈样肉芽肿晚期患者病情的复发率为44.44%。蕈样肉芽肿早期患者病情的复发率明显优于蕈样肉芽肿晚期患者,差异显著(P<0.05),具有统计学意义。结论 :对不同分期的蕈样肉芽肿患者使用窄谱中波紫外线进行治疗的效果均较好,均有助于缓解患者的临床症状,但对蕈样肉芽肿早期患者使用窄谱中波紫外线进行治疗的效果更佳。此法值得在临床上推广应用。
Objective: To explore the effect of using narrow-band UVB in patients with mycosis fungoides at different stages. Methods: The clinical data of 30 patients with mycosis fungoides admitted in our hospital from January 2010 to December 2014 were retrospectively analyzed. In our hospital, mycosis fungoidesⅠA, ⅠB andⅡA were classified as early stage patients, and mycosis fungoidesⅡB ~ ⅢB were classified as advanced stage patients. Our hospital on these 30 cases of different stages of patients with mycosis fungoides were treated with narrow band UVB, and then compare the effect of treatment. Results: After the treatment, the total effective rate of patients with early mycosis fungoides was 100%, and the total effective rate of patients with advanced mycosis fungoides was 61%. The total effective rate of early stage patients with mycosis fungoides was significantly higher than that of patients with advanced stage mycosis fungoides (P <0.05), which was statistically significant. The average number of patients treated with mycosis fungoides and the dose of irradiation were significantly better than those of patients with advanced mycosis fungoides (P <0.05), which was statistically significant. The incidence of mycosis fungoides was 8.33% in early stage and 44.44% in patients with advanced mycosis fungoides. Mycosis fungoides in patients with early stage of disease recurrence rate was significantly better than the late-stage patients with mycosis fungoides, the difference was significant (P <0.05), with statistical significance. Conclusion: The treatment of patients with mycosis fungoides of different stages with narrow-band UVB is better, which can help to alleviate the clinical symptoms of patients, but the early stages of mycosis fungoides are treated with narrow-band ultraviolet B The effect of treatment is better. This method is worth promoting in clinical application.