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目的:研究甲泼尼松龙辅助治疗肺炎支原体肺炎的效果及其免疫影响。方法:2008年1月～2012年12月唐山市妇幼保健院支原体肺炎患儿,采用随机数字法均分为两组,根据是否接受甲泼尼松龙辅助治疗分为观察组与对照组。对两组患儿治疗的临床效果,及治疗前后血清CRP、IL-2、IL-8、TNF-α水平进行比较。结果:观察组治疗显效率明显高于对照组(57.0%vs.28.0%,P<0.05);其无效率则低于对照组(5.4%vs.19.4%,P<0.05)。甲泼尼松龙辅助治疗支原体肺炎前后,血清CRP、IL-8、TNF-α水平降低,IL-2水平升高(P<0.05);甲泼尼松龙辅助治疗支原体肺炎后,血清CRP、IL-8、TNF-α水平降低,IL-2水平升高,与对照组治疗后相比较,差异均有统计学意义(P<0.05)。结论:甲泼尼松龙辅助治疗支原体肺炎能够较快的减轻肺部炎症反应,缓解临床症状,缩短治疗时间,但远期效果尚待进一步随访。
Objective: To study the effect of methylprednisolone adjuvant treatment of Mycoplasma pneumoniae pneumonia and its immune effects. Methods: From January 2008 to December 2012, children with mycoplasmal pneumonia in Tangshan MCH hospital were randomly divided into two groups according to whether they received adjuvant methylprednisolone treatment and were divided into observation group and control group. The clinical effects of treatment of two groups of children, and before and after treatment serum CRP, IL-2, IL-8, TNF-α levels were compared. Results: The effective rate of observation group was significantly higher than that of control group (57.0% vs.28.0%, P <0.05). The inefficiency rate of observation group was lower than that of control group (5.4% vs.19.4%, P <0.05). The level of serum CRP, IL-8 and TNF-α decreased and the level of IL-2 increased in patients with mycoplasma pneumonia after adjuvant methylprednisolone adjuvant therapy (P <0.05). After treatment with methylprednisolone for mycoplasma pneumonia, serum CRP, IL-8, TNF-α and IL-2 in the control group were significantly lower than those in the control group (P <0.05). Conclusions: Methylprednisolone adjuvant treatment of mycoplasma pneumonia can reduce lung inflammation, relieve clinical symptoms and shorten the treatment time, but the long-term effect needs further follow-up.