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目的研究HLA-DRB1的多态性,寻找急性脑梗死的致病易感基因和保护基因,为急性脑梗死的预防、早期诊断和治疗提供科学依据。方法采用PCR-SSOP方法对39例急性脑梗死患者和无偿献血志愿者99例进行HLA-DRB1的分型,分析病例组与对照组之间的差异。结果HLA-DRB1*13病例组和对照组间有显著性差异。OR值等于4.11,HLA-DRB1*13基因与脑梗死呈正相关性。结论HLA-DRB1*1可能是大连地区汉族成人急性脑梗死发病的一个致病易感基因或与其他基因协调致病。
Objective To study the polymorphism of HLA-DRB1 in search of susceptible genes and protective genes of acute cerebral infarction, and to provide a scientific basis for the prevention, early diagnosis and treatment of acute cerebral infarction. Methods HLA-DRB1 was genotyped in 39 patients with acute cerebral infarction and 99 volunteers by PCR-SSOP. The difference between case group and control group was analyzed. Results There was a significant difference between HLA-DRB1 * 13 case group and control group. OR value is equal to 4.11, HLA-DRB1 * 13 gene and cerebral infarction was positively correlated. Conclusions HLA-DRB1 * 1 may be a pathogenic susceptibility gene of adult Han people with acute cerebral infarction in Dalian or coordinate with other genes.