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左丙替林[(-)-R-α-(甲氨基)甲基-9,10-桥亚乙基蒽-9-(10H)-乙醇盐酸盐]是马普替林的羟基衍生物之一。临床研究已表明它与马普替林和阿米替林有等强抗抑郁疗效,而不影响神经末梢对去甲肾上腺素或5-HT的吸收抑制作用。本文研究左丙替林和已知抗抑郁药比较的药理作用。1.CNS:低剂量(30mg/kg,po)左丙替林对小鼠和大鼠的一般行为没有任何明显的作用。而在较高剂量(100mg/kg,po)它微弱地抑制小鼠翻正反射和自发运动的能动
Levodipropyl [(-) - R-α- (methylamino) methyl-9,10-ethanoanthracene-9- (10H) -ethanol hydrochloride] one. Clinical studies have shown that it has a strong antidepressant effect with maprotiline and amitriptyline, without affecting the inhibitory effect of nerve endings on norepinephrine or 5-HT uptake. This article studies the pharmacological effects of levodipin versus known antidepressants. 1. CNS: Low-dose (30 mg / kg, po) levodinib did not have any significant effect on the general behavior of mice and rats. While at a higher dose (100 mg / kg, po) it weakly inhibited the motility of the mouse against regular reflex and spontaneous movement