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在缺血性心脏病的病理生理机制中,心表面冠状动脉的舒缩和对药物反应的改变,可能起有重要作用。本文研究人体心表面冠状动脉对组胺、脱羟肾上腺素、五羟色胺、麦角新碱、碳酰胆碱和前列腺素内过氧化同功异构体(U-44069)的反应,并验证了钙池调节血管收缩的作用。方法:冠状动脉取自49个心脏,分别来自5组。A 组为4例心功能正常的供心者,平均年龄21岁。B 组为20例充血性心肌病终末期病人而接受心脏移植者,平均年龄为27.1±2.7岁,病程27.5±11.6月。C 组为17例严重缺血性心肌病而接受
In the pathophysiological mechanism of ischemic heart disease, the relaxation of cardiac coronary arteries and changes in response to drugs may play an important role. In this paper, we investigated the response of human cardiac superficial coronary arteries to histamine, phenylephrine, serotonin, ergometrine, carbachol, and prostaglandin endoperoxide isomers (U-44069) Regulate the role of vasoconstriction. METHODS: Coronary arteries were obtained from 49 hearts, each from 5 groups. A group of 4 patients with normal cardiac function for the donor, mean age 21 years. In group B, 20 patients with end-stage congestive cardiomyopathy underwent heart transplantation. The average age was 27.1 ± 2.7 years and the duration of disease was 27.5 ± 11.6 months. Group C received 17 patients with severe ischemic cardiomyopathy