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胰岛素样生长因子(IGF)系统在细胞增殖、转化、凋亡中起重要作用,与肿瘤的发生、发展密切相关,其已成为国内外肿瘤学研究领域的热点。通过介绍IGF的组成、结构及功能,阐述IGF中各成员在宫颈癌发生、发展及转移中的作用,探讨其与宫颈癌预后的关系,并从中找出有助于宫颈癌风险判断的因素。结合近年来的研究进展,综合分析IGF系统与宫颈癌的关系,为IGF系统在宫颈癌诊断、治疗提供一定的理论依据。
Insulin-like growth factor (IGF) system plays an important role in cell proliferation, transformation and apoptosis, and is closely related to the occurrence and development of tumors. It has become a hot spot in the field of oncology research at home and abroad. By introducing the composition, structure and function of IGF, this paper expounds the role of IGF members in the occurrence, development and metastasis of cervical cancer, and explores its relationship with the prognosis of cervical cancer, and finds the factors that contribute to the risk assessment of cervical cancer. Combined with the research progress in recent years, a comprehensive analysis of the relationship between IGF system and cervical cancer for the IGF system in the diagnosis and treatment of cervical cancer provide a theoretical basis.