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目的：研究复方丹参及川芎嗪注射液中药抗栓胶囊对小白鼠体内血栓形成及血浆组织型纤维溶酶原激活物（ｔ Ｐ Ａ）及其抑制物（ Ｐ Ａ Ｉ）的影响。方法：给不同组小鼠分别注射复方丹参及川芎嗪注射液、以及服用中药抗栓胶囊７ ｄ。用致栓药角叉菜胶诱发小鼠体内血栓形成。发色底物法测定血浆 ｔ Ｐ Ａ 及 Ｐ Ａ Ｉ活性。结果：复方丹参组及中药抗栓胶囊组小鼠尾部平均血栓形成长度百分数比血栓对照组明显缩短，复方丹参组、中药抗栓胶囊组血浆 Ｐ Ａ Ｉ低于血栓对照组，有显著性差异（ Ｐ＜ ００５）。结论：复方丹参、中药抗栓胶囊具有抗栓作用。其作用机理可能主要与可减少血浆 Ｐ Ａ Ｉ的释放有关。
Objective: To study the effect of compound salvia miltiorrhiza and ligustrazine injection antithrombotic capsule on thrombosis and plasma tissue plasminogen activator (t PA) and its inhibitor (PAI) in mice. METHODS: Different groups of mice were injected with Compound Salvia Miltiorrhiza and Ligustrazine Injection, and anti-thrombus capsules for 7 days. Suppository drug carrageenin was used to induce thrombosis in mice. The chromogenic substrate method was used to measure plasma t-P A and P A I activity. Results: The percentage of average thrombosis length in mice tail of compound Danshen group and traditional Chinese medicine anti-shuan capsule group was significantly shorter than that of thrombus control group. The plasma P A I of compound Danshen group and traditional Chinese medicine anti-shuai capsule group was lower than that of thrombus control group, with significant difference ( P< 005). Conclusion: Compound salvia miltiorrhiza and traditional Chinese medicine antithrombotic capsules have antithrombotic effects. Its mechanism of action may be mainly related to the reduction of plasma P A I release.