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报道了改善难溶药物溶出速率的一些新剂型的改进方法。(1)将难溶药物制备成玻璃状制剂如灰黄霉素和吲哚美辛;或与α-环糊精混合,用冷冻干燥法制备成包合物如尼泊金甲酯。另可用聚乙烯吡咯烷酮(PVP)和羟丙甲基纤维素(HPMC)两种包衣材料制备成肠溶制剂如硝苯啶。上述方法均可使药物溶出改善,从而使疗效提高;(2)对含有aclarubicin 的生物降解性的聚乳酸(PLA)微球用于临床28例原发肝癌患者进行评价,6个月的生存率达83.6%,由此拟进一步扩大对其它抗肿瘤药物PLA 缓释制剂系统给药的评价;(3)孔穴
An improved method of some new dosage forms to improve the dissolution rate of poorly soluble drugs has been reported. (1) Preparation of poorly soluble drugs into glassy preparations such as griseofulvin and indomethacin; or with α-cyclodextrin, and lyophilization to prepare clathrates such as methyl paraben. Another available polyvinylpyrrolidone (PVP) and hydroxypropylmethyl cellulose (HPMC) two coating materials prepared into enteric agents such as nifedipine. The above methods can improve the dissolution of the drug, so as to improve the curative effect. (2) Biodegradable polylactic acid (PLA) microspheres containing aclarubicin are used in the clinical evaluation of 28 patients with primary liver cancer. The 6-month survival rate Up to 83.6%, thus intends to further expand the evaluation of other systemic antitumor drug PLA sustained release formulations; (3)