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腹腔化疗能显著提高大肠癌治愈率及预防复发 ,同时也存在全身化疗的毒副作用及易产生耐药性 ,维拉帕米对化疗的辅助作用在实验与临床得到证实 ,联合应用羟基喜树碱 (ＨＣＰＴ)、5 -氟尿嘧啶 ( 5 Ｆｕ)及维拉帕米 (ＶＲＰ)在直肠癌患者术中及术后辅助化疗 ,能提高患者生存时间
Intraperitoneal chemotherapy can significantly improve the cure rate and prevent recurrence of colorectal cancer. At the same time, it also has the toxic and side effects of systemic chemotherapy and is easy to produce drug resistance. The adjuvant effect of verapamil on chemotherapy has been confirmed experimentally and clinically, combined with hydroxycamptothecin (HCPT),5-fluorouracil (5 Fu) and verapamil (VRP) in patients with rectal cancer and postoperative adjuvant chemotherapy can improve survival time