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目的回顾性分析原发性肺涎腺型肿瘤的临床特点、治疗及预后,以提高对原发性肺涎腺型肿瘤的认识和诊断率。方法收集2009年10月—2015年10月在四川大学华西医院经病理活体组织检查确诊的41例原发性肺涎腺型肿瘤患者的临床资料,分析原发性肺涎腺型肿瘤的临床特点、治疗及预后。结果 41例原发性肺涎腺型肿瘤患者占同期确诊的肺原发性恶性肿瘤的0.22%(41/18 738),其中男21例,女20例;年龄16~72岁,中位年龄43.6岁;病程1个月~6年;有吸烟史12例;腺样囊性癌23例,黏液表皮样癌15例,腺泡细胞癌3例。该类患者的临床症状、胸部影像学及纤维支气管镜表现均缺乏特异性。34例接受外科手术治疗,3例接受气管镜下肿瘤切除治疗,4例口服中药治疗;术后5例患者行同步放射治疗(放疗)和化学治疗(化疗),9例患者接受化疗,4例接受术后放疗。随访2~65个月,中位随访时间38个月,2例复发,6例出现远处转移,1例死亡。结论原发性肺涎腺型肿瘤临床症状无特异性,确诊依赖于病理学检查,接受外科手术治疗为主的综合治疗后,总体预后好于其他肺部恶性肿瘤。
Objective To retrospectively analyze the clinical features, treatment and prognosis of primary salivary gland tumors in order to improve their understanding and diagnosis of primary salivary gland tumors. Methods The clinical data of 41 patients with primary salivary gland tumor diagnosed by pathological biopsy from West China Hospital of Sichuan University from October 2009 to October 2015 were collected. The clinical features of primary salivary gland tumor , Treatment and prognosis. Results The 41 patients with primary salivary gland tumors accounted for 0.22% (41/18 738) of the patients with primary lung cancer diagnosed in the same period, including 21 males and 20 females, aged from 16 to 72 years, with a median age 43.6 years of age; duration of 1 month to 6 years; 12 cases of smoking history; adenoid cystic carcinoma in 23 cases, mucoepidermoid carcinoma in 15 cases, acinar cell carcinoma in 3 cases. The clinical symptoms of these patients, chest imaging and bronchoscopic performance of the lack of specificity. 34 patients underwent surgical treatment, 3 underwent endotracheal resection and 4 underwent oral traditional Chinese medicine. Five patients underwent concurrent radiotherapy and chemotherapy (chemotherapy), 9 received chemotherapy, and 4 received postoperative chemotherapy Accept postoperative radiotherapy. The patients were followed up for 2 to 65 months. The median follow-up time was 38 months. Two patients relapsed. Six patients had distant metastasis and one patient died. Conclusion The clinical manifestations of primary salivary gland tumors are nonspecific. The diagnosis depends on pathological examination. After the comprehensive treatment based on surgical treatment, the overall prognosis is better than other pulmonary malignancies.