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应用双单克隆抗体夹。法ＥＬＩＳＡ对９４例慢性肝病患者血清白细胞介素－８（ＩＬ－８）的水平进行了检测。结果３４例患者血清中检测出ＩＬ－８（３６．２％），检出率显著高于正常对照组（１０％，Ｐ＜０．０５），其中慢性活动性肝炎（ＣＡＮ）患者中检出率最高（６８％，Ｐ＜０．０１）。患者中测出的ＩＬ－８水平显著高于正常对照组（Ｐ＜０．０１），且与其血清胆红素（ＢＩＬ）水平呈正相关（γ＝０．４３４７，Ｐ＜０．０５）。我们的研究表明，约有１／３慢性肝病患者血清ＩＬ－８水平升高（以１５６ｎｇ／Ｌ为界值），并随肝脏炎症活动程度加重而增加，提示ＩＬ－８可能参与了慢性肝脏炎症损害过程，并能反映肝脏病变的活动状况。
Apply dual monoclonal antibody clamps. ELISA was used to detect the level of serum interleukin-8 (IL-8) in 94 patients with chronic liver disease. Results The serum levels of IL-8 (36.2%) were detected in 34 patients, the detection rate was significantly higher than that of the normal control group (10%, P <0.05), of which the patients with chronic active hepatitis The highest rate (68%, P <0.01). The level of IL-8 in patients was significantly higher than that of the normal control group (P <0.01), and positively correlated with the level of serum bilirubin (γ = 0.4347, P <0.05). Our study shows that about one third of patients with chronic liver disease serum IL-8 levels (156ng / L as a cut-off value), and increased with the degree of inflammatory activity of the liver increased, suggesting that IL-8 may be involved in chronic liver inflammation Damage the process, and can reflect the activity of liver disease.