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目的探讨妊娠期亚临床甲状腺功能减退(甲减)和甲状腺过氧化物酶抗体(TPOAb)阳性对妊娠结局的影响。方法比较200例亚临床甲减合并TPOAb阳性妊娠患者(观察组)和120例甲状腺功能正常的妊娠妇女(对照组,其中20例TPOAb阳性,100例TPOAb阴性)的妊娠结局。结果观察组妊娠高血压患病率(18.00%vs.8.33%)、流产率(26.00%vs.15.00%)、早产率(12.50%vs.4.17%)和胎盘早剥率(9.00%vs.1.67%)均高于对照组(P<0.05)。对照组中,TPOAb阳性妊娠妇女的流产率高于TPOAb阴性者(35.00%vs.14.00%)(P<0.05)。结论妊娠期亚临床甲减和TPOAb阳性会影响产妇的妊娠结局,需给予患者尽早的治疗。
Objective To investigate the effect of sub-clinical hypothyroidism (hypothyroidism) and thyroid peroxidase antibody (TPOAb) positive pregnancy outcomes on pregnancy outcome. Methods The pregnancy outcomes of 200 patients with subclinical hypothyroidism and TPOAb positive pregnancy (observation group) and 120 normal pregnant women with thyroid function (control group, 20 TPOAb positive and 100 TPOAb negative) were compared. Results The prevalence of gestational hypertension (18.00% vs.8.33%), abortion rate (26.00% vs.15.00%), preterm birth rate (12.50% vs.4.17%) and placental abruption rate (9.00% vs.1.67 %) Were higher than the control group (P <0.05). In the control group, the abortion rate in TPOAb-positive pregnant women was higher than that in TPOAb-negative women (35.00% vs.14.00%, P <0.05). Conclusion Subclinical hypothyroidism and TPOAb positive pregnancy during pregnancy will affect the pregnancy outcome of pregnant women, patients should be given as soon as possible treatment.