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特发性肺纤维化(IPE)是一种致命性疾病,目前的治疗方法对患者的预后起不到多大作用。博莱霉素引起的动物肺纤维化与人类IPE很相似。博莱霉素致肺纤维化在用药后28天内形成,最初14天是以炎症为主的急性期,后14天表现为纤维化期。在IPF和博莱霉素所致肺纤维化中,中性粒细胞起着一定作用。中性粒细胞弹性蛋白酶(NE)与一些人类肺损伤有关。ONO-5046·Na(2,2-二甲丙酸基,4-苯磺酰氨基,2-苯甲酰,N-氨基乙酸四水化钠)是一种低分子量人类NE特异性抑制剂,其对肺纤维化的作用尚未见报道。作者观察了该抑制剂对博莱霉素所致肺纤维化和急性肺损伤的作用,并对NE与其他炎症细胞的关系进行了研
Idiopathic pulmonary fibrosis (IPE) is a fatal disease and the current treatment does not play a significant role in the patient’s prognosis. Bleomycin caused animal lung fibrosis and human IPE is very similar. Bleomycin-induced pulmonary fibrosis in the formation of 28 days after treatment, the first 14 days is mainly based on the acute inflammation, 14 days after the performance of fibrosis. In IPF and bleomycin-induced pulmonary fibrosis, neutrophils play a role. Neutrophil elastase (NE) is associated with some human lung injury. ONO-5046Na (2,2-dipropionate, 4-phenylsulfonylamino, 2-benzoyl, N-glycine sodium hydrate) is a low molecular weight human NE specific inhibitor, Its role in pulmonary fibrosis has not been reported. The authors observed the effect of this inhibitor on bleomycin-induced pulmonary fibrosis and acute lung injury, and studied the relationship between NE and other inflammatory cells