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目的和方法为探讨急性脑梗死不同时期一氧化氮（NO）含量变化的临床意义，送检42例急性脑梗死患者不同时期的血清，采用Green改良法检测NO和以邻苯三酚自氧化法检测超氧化物歧化酶（SOD）含量，并配有30例正常对照。结果结果表明：脑梗死早期NO、SOD含量显著降低；急性期NO含量增高，并超过正常对照，而SOD含量进一步下降；脑梗死稳定期后，NO含量有所下降，接近正常水平，SOD含量增高，但仍低于正常。结论据上述结果提示，NO在急性脑梗死不同时期具有细胞毒性和组织保护双重作用，为临床寻求一种急性脑梗死的可能有效治疗方法提供了理论依据。
Objectives and Methods To investigate the clinical significance of the changes of nitric oxide (NO) content in different stages of acute cerebral infarction, the serum of 42 patients with acute cerebral infarction at different stages was sent for detection of NO by green modified method and pyrogallol autoxidation The content of superoxide dismutase (SOD) was detected and 30 normal controls were fitted. The results showed that: the content of NO and SOD in the early stage of cerebral infarction decreased significantly; the content of NO increased in acute phase and exceeded the normal control, while the content of SOD decreased further; the content of NO decreased after the stable period of cerebral infarction, close to the normal level, , But still below normal. Conclusions The above results suggest that NO has the dual role of cytotoxicity and tissue protection at different stages of acute cerebral infarction and provides a theoretical basis for the clinical search for a possible and effective treatment for acute cerebral infarction.