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目的 探讨奥美拉唑联合思密达对小儿危重病应激性上消化道出血的预防效果及机制。方法 122例危重病患儿随机分为2组,对照组在治疗原发病基础上,对症及支持等治疗;预防组在对照组治疗基础上加用奥美拉唑0.4mg/次,每日1次;思密达在<1岁1g/次,1~3岁2g/次,>3岁3g/次,每日3次,2药错开经胃管注入,连用7天,对两组患儿上消化道出血的发生率进行对比。结果 预防组上消化道出血的发生率为 3.22%,明显低于对照组31.67%, 有显著差异(P<0.01)。结论 奥美拉唑与思密达联合能有效地预防小儿危重病应激性上消化道出血的发生。
Objective To investigate the preventive effect and mechanism of omeprazole combined with Smecta on stress-induced upper gastrointestinal bleeding in critically ill children. Methods 122 cases of critically ill children were randomly divided into two groups, the control group on the basis of the treatment of primary disease, symptomatic and supportive treatment; prevention group based on the control group plus omeprazole 0.4mg / time, daily 1; Smectite <1 year old 1g / time, 1 to 3 years old 2g / time,> 3 years old 3g / times, 3 times a day, 2 drugs staggered through the tube into the tube, once every 7 days, The incidence of upper gastrointestinal bleeding were compared. Results The incidence of upper gastrointestinal bleeding was 3.22% in prevention group, which was significantly lower than that in control group (31.67%, P <0.01). Conclusion Omeprazole combined with Smecta can effectively prevent the occurrence of stress-induced upper gastrointestinal bleeding in pediatric patients.