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目的观察国产生物合成人胰岛素甘舒霖30R联合二甲双胍治疗磺脲类药物继发失效的效果。方法选取75例磺脲类药物继发失效的2型糖尿病患者,按单双日分为两组,甘舒霖治疗组38人,诺和灵对照组37人。治疗组用国产生物合成人胰岛素甘舒霖30R早晚餐前2次皮下注射,对照组采用诺和灵30R早晚餐前2次皮下注射,两组均同时给予二甲双胍0.5g,每日三次口服。结果治疗8周后,甘舒霖30R联合二甲双胍能有效的控制空腹血糖、2hPG以及HbA1C(P<0.05)。结论甘舒霖30R联合二甲双胍能有效治疗口服磺脲类降糖药继发性失效的2型糖尿病患者,降血糖疗效确切,不良反应少,价格便宜,适宜推广。
Objective To observe the effect of the domestic biosynthetic human insulin Gan Shu-lin 30R combined with metformin on the secondary failure of sulfonylureas. Methods Seventy-two patients with type 2 diabetes mellitus secondary to failure of sulfonylurea were divided into two groups on the basis of single and double day, 38 in Gansu-lin treatment group and 37 in Noroxen control group. Treatment group with domestic biosynthetic human insulin Gansu Lin 30R before and after breakfast subcutaneous injection of 2 times, the control group using Novolin 30R before and 2 times before and after subcutaneous injection, both groups were given metformin 0.5g, three times a day orally. Results After treatment for 8 weeks, Gan Shu-lin 30R combined with metformin could effectively control fasting blood glucose, 2hPG and HbA1C (P <0.05). Conclusions Ganshu Lin 30R combined with metformin can effectively treat patients with type 2 diabetes who have secondary failure of oral sulfonylurea hypoglycemic drugs. It has definite effect of reducing blood sugar, has few side effects, is cheap and is suitable for promotion.