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目的对上海地区无偿献血者血液中不规则抗体进行常规筛查,在进一步提高血液安全同时,也为寻找一个适合于血站大规模常规开展不规则抗体的筛查方法,提供参考依据。方法采用盐水介质与微量板木瓜酶法相结合的方法,对824 072例献血者进行不规则抗体筛查。结果 824 072例献血者血液样本中共检测出不规则抗体阳性1 246例,阳性率1.51‰。结论筛查无偿献血者血液中不规则抗体,可有效降低或避免溶血性输血反应;盐水介质与微量板木瓜酶法相结合的方法是适合血站大规模常规开展不规则抗体筛查的有效方法。
OBJECTIVE: To routinely screen for irregular antibodies in the blood of unpaid blood donors in Shanghai, and to further improve blood safety, and to find a suitable screening method for large-scale conventional irregular antibodies in blood stations. Methods A total of 824 072 blood donors were screened for irregular antibodies by a combination of saline medium and papain assay. Results A total of 1224 cases of irregular antibody were detected in 824 blood samples of 072 donors, the positive rate was 1.51 ‰. Conclusion The screening of irregular antibodies in the blood of unpaid blood donors can effectively reduce or avoid the hemolytic transfusion reaction. The combination of saline medium and papain enzymatic method is an effective method suitable for large-scale routine screening of irregular antibodies in blood stations .