A reactive C5 oleifns and methanol etheriifcation kinetic model based on E-R mechanism was established and three different types of reactors including the adiabatic ifxed-bed liquid reactor, the extal loop reactor and the mixed-phase reactor were constructed by Aspen Plus. The adaptability of reactive C5 oleifns to these reactors was studied and simulated using various gasoline fractions with different oleifns content. After the theoretical model was validated by the experimental data of the etheriifcation of three C5 light cut fractions from different gasoline sources in different reactors, the simulated isoamylene conversion with reactive C5 olefin contents increasing from 10% to 60% was studied in the three different types of reactors for etheriifcation with methanol, respectively. Test results show that there is an obvious adaptability of the feedstock composition to the reactor type to achieve a high conversion.