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肺癌是常见的恶性肿瘤,对全世界造成巨大的社会负担。目前对肺癌的早期诊断和治疗仍较为困难,发现新的特异性肿瘤标志物至关重要。热休克蛋白40,即HSP40是跨物种存在的高度保守的蛋白质家族,其在人类许多肿瘤包括肺癌中呈异常表达,在细胞应激保护、蛋白质折叠、重折叠或聚集与降解,以及蛋白质移位等方面有重要作用。本文综述了近年来关于HSP40蛋白的结构、功能以及其与肺癌的关系,为该领域的研究提供一定的参考。
Lung cancer is a common malignancy, causing a huge social burden to the world. The current diagnosis and treatment of lung cancer is still more difficult to find new specific tumor markers is essential. Heat shock protein 40, HSP40, is a highly conserved family of proteins that exists across species and is aberrantly expressed in many human cancers, including lung cancer, in cell stress protection, protein folding, refolding or aggregation and degradation, and protein translocation Etc. have an important role. This review summarizes the recent studies on the structure and function of HSP40 protein and its relationship with lung cancer and provides some references for the research in this field.