目的　研究终末期肾功能衰竭维持性血液透析患者血清leptin质量浓度与营养状态的关系。方法　2 0 0 1- 11～ 2 0 0 3- 0 4测定 2 9例中山大学附属三院住院入选患者的肱三头肌皮褶厚度 (TSF)、体重指数 (BMI)、脂肪含量(Fat% )、外周淋巴细胞计数、血清白蛋白、球蛋白、甘油三酯、胆固醇、总铁结合力、肾功能和瘦素等指标 ,营养不良 -炎症评分 (MIS)评价营养状况。结果　血清瘦素质量浓度与TSF、BMI、FAT %及MIS评分呈明显的正相关 (P <0 0 5 )。结论　瘦素可以作为评价脂肪含量的营养指标之一 ,可以作为评价患者预后的指标之一 Objective To study the relationship between serum leptin concentration and nutritional status in maintenance hemodialysis patients with end-stage renal failure. Methods 2 0 0 1- 11 ~ 2 0 0 3- 0 4 Determination of 29 patients hospitalized in Sun Yat-sen Affiliated Hospital of triceps skinfold thickness (TSF), body mass index (BMI), fat content (Fat% ), Peripheral lymphocyte count, serum albumin, globulin, triglyceride, cholesterol, total iron binding, renal function and leptin, malnutrition-inflammation score (MIS) Results Serum leptin concentration was positively correlated with TSF, BMI, FAT% and MIS score (P <0.05). Conclusion Leptin can be used as one of the nutritional indicators to evaluate the fat content, which can be used as an index to evaluate the prognosis of patients