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目的本研究的目的旨在分析脑出血患者红细胞(RBC)水平与全因死亡的相关性。方法我们纳入了2000年至2001年共479例脑出血患者并平均随访3.7年,其中男性298例(62.2%),平均年龄(58.6±9.8)岁。根据患者入院时红细胞浓度四分位值将患者分为四组,即RBC数量第1分位(RBC≤4.0×10~(12)/L)组(Q1组,n=114),RBC数量第2分位(4.04.8×10~(12)/L)组(Q4组,n=119)。收集患者入院的基线资料及静脉血标本,分析各项指标,终点事件定义为全因死亡。结果 479例脑出血患者总全因死亡率为22.1%(110/479)。以Q1组为基准进行计算,Q2组(13.2%,15/114)、Q3组(15.2%,20/132)组患者全因死亡率低于Q1组(26.3%,30/114),差异均有统计学意义(P<0.05),但是Q4组(31.1%,37/119)患者全因死亡率与Q1组(26.3%,30/114)相比无统计学意义(P>0.05)。在调整了年龄,性别等影响预后因素后,Q2(HR=0.439,95%CI=0.227-0.851,P=0.015)、Q3(HR=0.506,95%CI=0.273-0.936,P=0.030)较Q1组均对脑出血患者全因死亡具有保护作用,而Q4(HR=1.047,95%CI=0.596-1.840,P=0.872)与Q1组相比差异没有统计学意义。结论红细胞水平与脑血栓患者全因死亡相关。
Purpose The purpose of this study was to analyze the association of erythrocyte (RBC) levels with all-cause mortality in patients with intracerebral hemorrhage. METHODS: We enrolled 479 patients with ICH from 2000 to 2001 and followed up for an average of 3.7 years, of whom 298 were male (62.2%) with an average age of 58.6 ± 9.8 years. The patients were divided into four groups according to the quartile of erythrocyte concentration at the time of admission: the first RBC (RBC≤4.0 × 10-12 / L) group (Q1 group, n = 114), the number of RBC (RBC≤4.4 × 10-12 / L) group (Q2 group, n = 114), RBC number 3 (4.4 4.8 × 10-12 / L) group (Q4 group, n = 119). Baseline data and venous blood samples were collected from hospitalized patients, and various indicators were analyzed. End-point events were defined as all-cause death. Results The total all-cause mortality of 479 patients with cerebral hemorrhage was 22.1% (110/479). All-cause mortality in Q2 group (13.2%, 15/114) and Q3 group (15.2%, 20/132) was lower than that in Q1 group (26.3%, 30/114) (P <0.05). However, the all-cause mortality rate in Q4 group (31.1%, 37/119) was not significantly different from that in Q1 group (26.3%, 30/114) (P> 0.05). After adjustment for age, gender and other factors that affected the prognosis, Q (HR = 0.506, 95% CI = 0.273-0.936, P = 0.030) Q1 group all had a protective effect on all-cause death in patients with ICH, but Q4 (HR = 1.047, 95% CI = 0.596-1.840, P = 0.872) had no significant difference compared with Q1 group. Conclusion Erythrocyte levels are related to all-cause mortality in patients with cerebral thrombosis.