目的　探讨肾移植前后尿液血栓素B2 (TXB2 )测定的临床意义。方法　采用酶免疫法分别测定尿毒症患者肾移植前后和健康人尿液TXB2 含量。结果　 6 6例健康人尿液TXB2 水平为 (2 92 1.6 1± 883.89)ng/L ;75例尿毒症患者为 (6 2 1.5 3± 2 2 7.0 2 )ng/L ,显著低于健康人 (P <0 .0 1)。肾移植术后为 (184 3.35± 90 7.13)ng/L ,较术前显著升高 (P <0 .0 1)。 结论　尿液TXB2 对于尿毒症患者肾移植术疗效判断有一定价值 Objective To investigate the clinical significance of urine TXB2 before and after renal transplantation. Methods Enzyme immunoassay was used to determine TXB2 levels in urine of healthy people before and after renal transplantation. Results The urinary TXB2 level in 6 healthy subjects was (2 92 1.6 1 ± 883.89) ng / L and that in 75 uremic patients was (62.5 3 ± 2 2 7.0 2) ng / L, which was significantly lower than that in healthy people P <0 .0 1). After kidney transplantation, it was (184 3.35 ± 90 7.13) ng / L, which was significantly higher than that before operation (P <0.01). Conclusion Urine TXB2 has some value in judging the efficacy of renal transplantation in patients with uremia