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米非司酮(代号RU486)是一种作用于受体水平的孕激素拮抗剂,兼有抗糖皮质激素的作用,临床上主要用于终止早孕、紧急避孕和引产等。利用其抗孕激素活性治疗子宫肌瘤、子宫内膜异位症、异位妊娠等也获得成功。研究发现,米非司酮可抑制卵巢癌上皮细胞的生长,对于耐药性卵巢癌具有一定的疗效。现对米非司酮治疗耐药性卵巢癌的作用机制、体内体外的研究进展予以综述。
Mifepristone (code: RU486) is a progestin antagonist that acts on the receptor level and plays an anti-glucocorticoid effect. It is mainly used to terminate early pregnancy, emergency contraception and induction of labor in clinic. The use of its anti-progesterone activity in the treatment of uterine fibroids, endometriosis, ectopic pregnancy also achieved success. The study found that mifepristone can inhibit the growth of epithelial ovarian cancer cells for resistant ovarian cancer has a certain effect. Now on the mechanism of mifepristone treatment of drug-resistant ovarian cancer, in vitro and in vivo research are reviewed.