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目的探讨胃液胃动素（Ｍｏｔｉｌｉｎ，ＭＴＬ）与慢性胃炎、溃疡病及上消化道癌的关系。方法空腹胃镜检查时抽取胃液３ｍｌ，用放射免疫法测定其ＭＴＬ含量。共检测对照组２１例，慢性胃炎３１例，消化性溃疡２１例，上消化道癌２５例。结果慢性胃炎组ＭＴＬ无明显变化，消化性溃疡组及上消化道癌组ＭＴＬ明显升高（Ｐ＜０．０５），且上消化道癌组升高幅度明显大于消化性溃疡（Ｐ＜０．０５）。结论胃液胃动素与消化性溃疡及上消化道癌的发病可能有一定关系；测定空腹ＭＴＬ含量为判别消化道疾病提供一种新的指标。
Objective To investigate the relationship between motilin (MTL) and chronic gastritis, ulcer disease and upper gastrointestinal cancer. Methods Fasting gastroscopy during gastric juice extract 3ml, with radioimmunoassay MTL content. A total of 21 cases of control group were detected, 31 cases of chronic gastritis, peptic ulcer in 21 cases, 25 cases of upper gastrointestinal cancer. Results There was no significant difference in MTL between chronic gastritis group and MTL group (P <0.05) in peptic ulcer group and upper digestive tract cancer group, and the increase extent in upper digestive tract cancer group was significantly higher than that in peptic ulcer group (P <0. 05). Conclusion Gastric motilin may be related to the incidence of peptic ulcer and upper digestive tract cancer. The determination of fasting MTL content provides a new indicator for the diagnosis of gastrointestinal diseases.