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目的研究防脱育发精华露的急性毒性和遗传毒性,为其提供毒理学安全性实验依据。方法依照《化妆品卫生规范》(2007年版)对防脱育发精华露进行急性眼刺激性、多次皮肤刺激性、皮肤变态反应、皮肤光毒性、体外哺乳动物细胞染色体畸变及Ames试验。结果防脱育发精华露的急性眼刺激性试验结果为轻刺激性,急性皮肤刺激性试验结果为无刺激性,未见皮肤变态反应和皮肤光毒性,Ames试验阴性,体外哺乳动物细胞染色体畸变试验阴性。结论防脱育发精华露呈现轻度的眼刺激性,未见其他急性毒性和遗传毒性。
Objective To study the acute toxicity and genotoxicity of anti-hair-removing essence and provide experimental basis for its toxicological safety. Methods Acute ocular irritation, multiple skin irritation, skin allergy, skin phototoxicity, chromosome aberration in mammalian cells in vitro and Ames test were performed according to “Hygienic Standard for Cosmetics” (2007 edition). Results Acute eye irritation test results of anti-hair removal hair lotion were light irritant, acute skin irritation test results were non-irritating, no skin allergy and skin phototoxicity, Ames test negative, in vitro mammalian chromosome aberrations Test negative. Conclusion The anti-haircare hair extract shows mild eye irritation, no other acute toxicity and genotoxicity.