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现行的流感疫苗为甲型流感H1N1、H3N2和乙型流感三价灭活疫苗,以前未曾免疫过的9岁以下儿童需接种2次,且在幼婴中的免疫原性不稳定,以致不易在儿童中推广使用。一种新的减毒活疫苗可望替代现行的疫苗。这种甲型和乙型流感减毒疫苗是用在低温(25℃)下连续传代得到的重配的冷适应(ca)毒株制备的。单价甲型或乙型流感疫苗在儿童中是安全的并具有免疫原性,作者对2月龄至3岁儿童鼻内免疫二价甲型流感减毒活疫苗,并对其合适剂量、安全性和免疫原性进行了研究。
The current influenza vaccine is a trivalent inactivated vaccine against influenza A H1N1, H3N2 and influenza B, and children under 9 years of age who have not previously been immunized need to be vaccinated twice and the immunogenicity in infants is not so stable Children to promote the use of. A new live attenuated vaccine is expected to replace the current vaccine. The influenza A and B attenuated vaccines were prepared using a reconstituted cold adapted (ca) strain that was serially passaged at low temperature (25 ° C). The monovalent influenza A or B vaccine is safe and immunogenic in children. The authors immunized mice from 2 months to 3 years of age intranasally with a live attenuated attenuated influenza A vaccine and evaluated the appropriate dosage, safety And immunogenicity were studied.