amorolfine(Ro 14-4767)即苯丙基1,4氧氮环已烷(phenyl-propyl morpholine),是一种新推出的局部抗真菌药物,体内外试验已发现此药具有高度的抗皮肤癣菌和酵母菌作用。作者采用双盲平行对照研究评价此药与联苯苄唑对皮肤癣菌病的治疗情况。共选232例(有9例退出)皮肤癣菌病患者,直接镜检与真菌培养皆为阳性,年龄16岁以上(含16岁),病程3天至40年,多为足癣、体癣与股癣。孕妇或皮损伴细菌感染者、毛发癣菌病及甲癣病,以及疗前2周或疗中需用抗真菌药物者除外。病人随机分4组,分别外用0.125%、0.25%,0.5%的 amorolfine 和1% Amorolfine (Ro 14-4767), a phenylpropyl morpholine, is a newly introduced topical antifungal drug found to be highly resistant to dermatophytes in vitro and in vivo Bacteria and yeast effect. The authors used a double-blind, parallel-controlled study to evaluate the treatment of dermatophytosis with this drug and bifonazole. A total of 232 cases (9 out) dermatophytosis patients, direct microscopy and fungal culture are positive, more than 16 years of age (including 16 years), duration of 3 days to 40 years, mostly tinea pedis, body ringworm With jock itch. Pregnant women or lesions associated with bacterial infections, trichophyton mentagrophytes and onychomycosis, and 2 weeks before treatment or treatment with anti-fungal drugs are required. Patients were randomly divided into 4 groups, respectively, with topical 0.125%, 0.25%, 0.5% amorolfine and 1%