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对２８例慢性肝炎、２３例肝炎性肝硬化及２６例原发性肝癌患者血清中ＩＬ－１、ＩＬ－８及ＴＮＦα活性进行了测定。结果表明，慢性肝炎患者ＩＬ－１、ＩＬ－８及ＴＮＦα活性分别为１５３８．３±３８６．５ｐｇ／ｍｌ，５０６．５±１３１．３ｐｇ／ｍｌ及２１２．６±９８．４ｐｇ／ｍｌ，明显高于对照组（Ｐ＜０．０１）；肝炎性肝硬化患者ＩＬ－１、ＩＬ－８及ＴＮＦα活性分别为２１６２．８±４３６．６ｐｇ／ｍｌ，６８２．６±２０４．５ｐｇ／ｍｌ及２４１．５±１０９．６ｐｇ／ｍｌ，明显高于对照组（Ｐ＜０．０１）；原发性肝癌患者ＩＬ－１、ＩＬ－８活性分别为６３２．６±１０７．６ｐｇ／ｍｌ，３１２．８±９５．８ｐｇ／ｍｌ，与对照组比较，ＩＬ－１活性明显升高（Ｐ＜０．０５），ＩＬ－８活性程度升高，但无明显差异（Ｐ＞０．０５）ＴＮＦα活性为３２１．６±１８３．２ｐｇ／ｍｌ，明显高于对照组。亦对上述３种细胞因子与慢性肝炎、肝硬化发生发展关系进行了初步分析与探讨。
The serum levels of IL-1, IL-8 and TNFα in 28 patients with chronic hepatitis, 23 patients with liver cirrhosis and 26 patients with primary liver cancer were determined. The results showed that the activities of IL-1, IL-8, and TNFα in patients with chronic hepatitis were 1538.3±386.5 pg/ml, 506.5±131.3 pg/ml, and 212.6±98.4 pg/ml, respectively. In the control group (P<0.01), the activity of IL-1, IL-8 and TNFα in patients with hepatic cirrhosis were 2162.8±436.6 pg/ml, 682.6±204.5 pg/ml and 241. 5±109.6pg/ml, significantly higher than the control group (P<0.01); the activity of IL-1 and IL-8 in primary liver cancer patients was 632.6±107.6pg/ml, respectively, 312.8± 95.8pg/ml, compared with the control group, IL-1 activity was significantly increased (P <0.05), IL-8 activity increased, but no significant difference (P> 0.05) TNFα activity was 321. 6±183.2pg/ml, significantly higher than the control group. The relationship between the above three kinds of cytokines and the development of chronic hepatitis and cirrhosis was also analyzed and discussed.