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SM－3属于1-取代咪唑衍生物，具有高效体外杀精作用。本文采用SM－3栓剂进行兔体内抗生育试验。结果表明，SM－3栓剂在雌兔人工授精前经阴道给药后产生显著的抗生育效果。30mg／枚组给药的家兔，无一只妊娠（妊娠率0％）；6mg／枚组给药的家兔，仅一只妊娠（妊娠率20％）；而对照组家兔、空白栓剂组家兔全部妊娠（妊娠率100％）。
SM-3 belong to 1-substituted imidazole derivatives, with efficient in vitro spermicidal effect. In this paper, SM-3 suppositories for in vivo anti-fertility test in rabbits. The results showed that SM-3 suppositories produced significant anti-fertility effects after vaginal administration prior to artificial insemination of female rabbits. There was only one pregnancy (20% pregnancy rate) in rabbits given 6mg / dose, while rabbits in control group, blank suppositories Group of rabbits all pregnancy (pregnancy rate 100%).