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背景:有研究报道剧烈运动能增加血液中骨髓祖细胞(如CD34~+细胞)数量,但尚未见研究报道抗阻运动后循环CD34~+细胞的变化。本研究旨在验证肘关节屈肌离心运动后血液中CD34~+细胞数量增加但恢复期减少,其数量变化幅度与肌肉损伤程度有关。方法:9名男性(28.0±6.6岁)用非惯用侧上肢完成10组(每组6次)最大自主肘关节屈肌离心运动,其中6名男性4周后用同一侧手臂完成同样的运动。在运动前、运动后、运动后2、24、48、72、96 h测量间接标记的肌肉损伤变化、白细胞分类计数(白细胞总数、中性粒细胞、淋巴细胞和单核细胞)以及血液中的CD34~+细胞数量。结果:离心运动后,最大自主等长收缩力矩显著缩小(p<0.05),延迟性肌肉酸痛增加,血浆肌酸激酶活性增加。然而,白细胞无显著性变化,CD34~+细胞发生明显变化。与第一次运动后相比,第二次运动后肌肉损伤标记物的变化显著减小(p<0.05)。但两次运动前后,白细胞和CD34~+细胞的变化无显著不同。结论:研究结果不能证实提出的假设,表明肘关节屈肌离心收缩诱导的肌肉损伤对CD34~+循环细胞没有影响。
BACKGROUND: Severe exercise has been reported to increase the number of bone marrow progenitor cells (such as CD34 + cells) in the blood. However, no study has reported any changes in circulating CD34 + cells after anti-exercise exercise. The aim of this study was to verify the increase in the number of CD34 + cells in the blood after eccentric exercise in the elbow flexor but with a decrease in convalescence, the magnitude of which is related to the extent of muscle damage. METHODS: Nine men (28.0 ± 6.6 years) performed a maximum of 10 pairs of elbow flexors (6 in each group) with non-dominant upper extremities, and 6 men completed the same exercise with the same arm four weeks later. Indirectly labeled muscle damage changes, leukocyte count (total leukocytes, neutrophils, lymphocytes and monocytes), and changes in blood before, 2, 24, 48, 72, 96 h after exercise were measured CD34 ~ + cell number. RESULTS: After eccentric exercise, the maximal voluntary isometric contraction torque was significantly reduced (p <0.05), prolonged muscle soreness increased, and plasma creatine kinase activity increased. However, no significant changes in white blood cells, CD34 ~ + cells significantly changed. Compared with the first exercise, changes in muscle injury markers after the second exercise were significantly reduced (p <0.05). However, before and after exercise twice, there was no significant difference in the changes of leukocytes and CD34 ~ + cells. CONCLUSIONS: The results of this study do not corroborate the hypotheses proposed, suggesting that muscle damage induced by eccentric contraction of the elbow flexors has no effect on CD34 + circulating cells.