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近年有关化疗或/和放疗引起急性非淋巴性白血病的报告不断增加。这种继发的白血病通常经过几年的潜伏期后才发生,病程短暂,迅速死亡。Rambam 医药中心血液病科于1975年12月～1982年8月收治93例急性白血病,其中15例曾接受化疗或/和放疗。女性9例,男性6例。诊断急性白血病时平均年龄为58岁(29～80岁)。原发病为:非何杰金氏淋巴瘤、何杰金氏病、多发性骨髓瘤和口乳腺癌各3例,精原细胞瘤、喉癌和强直性脊椎炎各1例。11例接受化疗伴有或不伴放疗,4例单纯放射治疗。本组病例于治疗开始后10月～30年(平均94个月)发生急性白血病。4例单纯放疗的潜伏期相当长(48月～30年,平均201个月),而11例化疗伴有或不伴放疗的潜
In recent years, reports of chemotherapy-induced or / and radiotherapy-induced acute non-lymphoid leukemia have been increasing. This secondary leukemia usually occurs after a few years of incubation period, short duration, rapid death. The Department of Hematology, Rambam Medical Center admitted 93 patients with acute leukemia from December 1975 to August 1982, 15 of whom received chemotherapy or radiotherapy. 9 females, 6 males. The average age of diagnosis of acute leukemia is 58 years old (29 to 80 years old). Primary disease: non-Hodgkin’s lymphoma, Hodgkin’s disease, multiple myeloma and oral and breast cancer in 3 cases, seminoma, laryngeal cancer and ankylosing spondylitis in 1 case. Eleven patients received chemotherapy with or without radiotherapy and four patients received radiotherapy alone. This group of patients in the treatment of 10 months to 30 years (average 94 months) acute leukemia. 4 cases of radiotherapy alone had a long incubation period (48 months to 30 years, an average of 201 months), while 11 cases of chemotherapy with or without radiotherapy