论文部分内容阅读
既往认为,孕妇的游离胰岛素不能通过胎盘,胎儿和羊水中的胰岛素完全由胎儿产生。但Yalow等报道,从注射过动物胰岛素并有抗胰岛素抗体的两例IDDM孕妇的胎儿脐带血中,确实检出了动物胰岛素。为了验证母体胰岛素能否通过胎盘进入胎儿并对胎儿产生生物效应,作者测定了51名IDDM母亲的婴儿脐带血,45例用牛或猪胰岛素,6例从妊娠第6周起用人胰岛素治疗。在孕期后三个月平均用量为1.06±0.5U/kg,平均糖化血红蛋白含量为8.2±1.7%(正常值<8.5%)。作者采用高分辨液相色谱法可分辨人、牛、猪三种胰岛素,同时用放射免疫分析法测定脐带血胰岛素含量和抗胰
In the past that pregnant women can not pass the free insulin in the placenta, fetal and amniotic fluid insulin completely produced by the fetus. However, Yalow et al. Reported that animal insulin was indeed detected in fetal umbilical cord blood of two IDDM pregnant women injected with animal insulin and having anti-insulin antibodies. In order to verify that maternal insulin can enter the fetus through the placenta and have a biological effect on the fetus, the authors measured cord blood from 51 IDDM mothers, 45 with cow or porcine insulin, and 6 with human insulin from the 6th week of gestation. The average amount of glycosylated hemoglobin during the three months after pregnancy was 1.06 ± 0.5 U / kg with an average of 8.2 ± 1.7% (normal <8.5%). The author uses high-resolution liquid chromatography to identify three kinds of human, cattle, pig insulin, while radioimmunoassay determination of umbilical cord blood insulin levels and anti-pancreatic