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药理作用 ＡＷＤ 12 2 81是强效高选择性磷酸二酯酶 4 (ＰＤＥ 4 )同工酶抑制剂 ,ＩＣ50 为 9.7ｍｍｏｌ·Ｌ- 1。在炎症细胞内主要的磷酸二酯酶同工酶是ＰＤＥ 4 ,调节环腺苷酸水平的细胞信号转导级联反应。ＰＤＥ 4抑制剂增加细胞内环腺苷酸水平 ,因而调节细胞功能 (如降
Pharmacological Action AWD 12 2 81 is a potent and highly selective phosphodiesterase 4 (PDE 4) isoenzyme inhibitor with IC50 of 9.7 mmol·L -1. The major phosphodiesterase isoenzyme in inflammatory cells is PDE 4, a cell signaling cascade that regulates cyclic adenosine levels. PDE 4 inhibitors increase intracellular adenylate levels and thus regulate cell function (eg, down