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目的:探讨血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)在原发性肝癌(PHC)组织中的表达及病理诊断价值。方法:采用免疫组化法,检测80例PHC标本和30例正常组织中VEGF和MMP-9的表达。结果:PHC组VEGF和MMP-9阳性表达率分别为68.8%、62.5%,均显著高于对照组(23.3%、26.7%),相比较有显著性差异(P<0.05)。肿瘤直径≥5 cm、无包膜和低分化肿瘤组织中VEGF和MMP-9阳性表达均显著高于肿瘤直径<5 cm、包膜完整和高中分化肿瘤组,相比较有显著性差异(P<0.05);而VEGF和MMP-9阳性表达在不同性别和年龄构成之间、有癌栓组和无癌栓组之间、AFP阳性组和阴性组之间差异无统计学意义(P>0.05)。结论:VEGF和MMP-9在PHC组织中呈高表达,VEGF和MMP-9可以作为PHC的预后指标。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in primary hepatocellular carcinoma (PHC) and their pathological value. Methods: Immunohistochemistry was used to detect the expression of VEGF and MMP-9 in 80 PHC specimens and 30 normal tissues. Results: The positive rates of VEGF and MMP-9 in PHC group were 68.8% and 62.5%, respectively, which were significantly higher than those in control group (23.3% and 26.7%, P <0.05). The positive expression of VEGF and MMP-9 in non-enveloped and poorly-differentiated tumors were significantly higher than those with tumor diameter> 5 cm in tumors with a diameter of less than 5 cm, complete capsule and high differentiated tumors (P < 0.05). There was no significant difference between AFP positive group and negative group (P> 0.05). The positive expression of VEGF and MMP-9 in different gender and age constitution, . Conclusion: VEGF and MMP-9 are highly expressed in PHC tissues, and VEGF and MMP-9 can be used as prognostic indicators of PHC.