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目的:探讨泼尼松联合氨甲苯酸注射液对过敏性紫癜患者的疗效及对患者炎症因子和凝血功能的影响。方法:过敏性紫癜患者98例随机分为观察组49例与对照组49例。对照组采用泼尼松片治疗,观察组在对照组基础上加用氨甲苯酸注射液。两组疗程均为4周。比较两组治疗疗效,治疗前后血清炎症因子和凝血功能变化,腹痛消失时间、紫癜消失时间及关节疼痛消失时间及不良反应情况。结果:观察组治疗总有效率93.88%,高于对照组的73.47%(P<0.05)。治疗后,两组血清IL-12水平增加、IL-15和IL-23水平降低、D-D二聚体、Fib水平降低;且观察组血清IL-12水平高于对照组,IL-15、IL-23水平,以及D-D二聚体、Fib水平均低于对照组(P<0.05)。观察组腹痛消失时间、紫癜消失时间及关节疼痛消失时间均明显短于对照组(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:泼尼松联合氨甲苯酸注射液治疗过敏性紫癜患者疗效显著,可明显改善血清炎症因子水平和凝血功能,且安全性良好,优于单用泼尼松治疗。
Objective: To investigate the efficacy of prednisone combined with trimethoprim injection on patients with allergic purpura and its effect on inflammatory factors and coagulation function. Methods: 98 patients with allergic purpura were randomly divided into observation group 49 cases and control group 49 cases. The control group was treated with prednisone tablets. The observation group was given aminotoluene injection on the basis of the control group. Two courses of treatment were 4 weeks. The curative effects of two groups were compared. Serum inflammatory factors and coagulation function changes, disappearance of abdominal pain, disappearance of purpura, disappearance of joint pain and adverse reactions were observed before and after treatment. Results: The total effective rate of the observation group was 93.88%, which was higher than that of the control group (73.47%, P <0.05). After treatment, serum IL-12 level increased, IL-15 and IL-23 levels decreased, DD dimer and Fib level decreased in both groups. The level of IL-12 in the observation group was higher than that in the control group 23 levels, and DD dimers, Fib levels were lower than the control group (P <0.05). The disappearance time of abdominal pain, the disappearance of purpura and the disappearance of joint pain in the observation group were significantly shorter than those in the control group (P <0.05). There was no significant difference between the two groups in the incidence of adverse drug reactions (P> 0.05). Conclusions: Prednisone combined with trimethoprim injection in the treatment of patients with allergic purpura significantly effect, can significantly improve serum levels of inflammatory cytokines and coagulation, and good safety, superior to prednisone alone.