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目的回顾总结亲属活体肾移植受者围手术期的临床特点。方法收集119例亲属活体肾移植受者对照同期234例尸体肾移植受者,比较两组供肾热、冷缺血时间、供肾血管长度、植肾手术时间、术后平均住院时间、供受者HLA错配率、术后3d血肌酐下降速度、DGF发生率、急排发生率、1年人/肾存活率。结果亲属活体肾移植组供肾血管长度、供肾热、冷缺血时间、术后平均住院时间、HLA六位点法错配率、DGF、急排发生率均明显小于尸体肾移植组(P<0.01),而手术时间、术后3d血清肌酐下降速度、1年人/肾存活率亲属活体肾移植组均明显大于尸体肾移植组(P<0.01)。结论亲属活体肾移植的近期临床疗效明显优于尸体肾移植,远期(>1年)的临床效果比较有待进一步追踪观察。在有条件、技术成熟的移植中心亲属活体肾移植是患者家族内自救互救的重要途径。
Objective To review and summarize the clinical features of perinatal renal transplant recipients. Methods A total of 234 renal transplant recipients of living-related renal transplant recipients were enrolled in this study. The renal transplant recipients were compared between the two groups for renal heat, cold ischemia, blood supply to the kidneys, operation time for renal transplantation, average postoperative hospital stay, HLA mismatch rate, the rate of decline of serum creatinine, the incidence of DGF, the incidence of acute rejection and the one-year human / kidney survival rate after operation. Results The length of renal blood supply, renal heat supply, cold ischemia time, average postoperative hospital stay, HLA-6 mismatch rate, incidence of DGF and emergency placentation in relative living donor kidney transplantation group were significantly lower than those in renal transplantation group <0.01). However, the time of operation, the rate of decline of serum creatinine and the relative survival of 1 year old / alive kidney transplantation group were significantly larger than those of the cadaver kidney transplantation group (P <0.01). Conclusion Relative clinical efficacy of living donor kidney transplantation is better than that of cadaveric kidney transplantation. The clinical effect of long-term (> 1 year) remains to be further traced. In conditional, well-established transplant center relatives of living kidney transplantation is an important way of self-help and mutual aid within the patient’s family.