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目的:探讨孕妇血清甲胎蛋白值持续增高与胎儿宫内缺氧及围产儿预后的关系。方法:以2006年7月～2010年6月门诊建立孕妇保健手册、检测血清甲胎蛋白值持续增高的76例孕妇作为观察对象(监测组),随机抽取同期建卡的孕妇150例作为对照组,比较两组胎儿宫内窘迫、新生儿窒息、新生儿缺血缺氧性脑病的发生率及剖宫产率。结果:监测组胎儿宫内窘迫、新生儿窒息、新生儿缺血缺氧性脑病的发生率均明显高于对照组(P<0.05),其剖宫产率亦高于对照组(P<0.01)。结论:孕妇甲胎蛋白持续增高提示胎儿存在宫内缺氧,需及时予以改善宫腔内环境及缺氧状态,临产时应放宽手术指征,尽快结束妊娠并对新生儿及时进行治疗,以减少围产儿不良结局。
Objective: To investigate the relationship between serum alpha-fetoprotein (AFP) value and fetal hypoxia and the prognosis of perinatal fetus. Methods: From July 2006 to June 2010, 76 maternal health manuals were set up to detect 76 pregnant women with continuously increasing serum alpha-fetoprotein values (monitoring group). 150 pregnant women were randomly selected as the control group The incidences of fetal distress, neonatal asphyxia, neonatal hypoxic-ischemic encephalopathy and cesarean section rates were compared between the two groups. Results: The incidences of fetal distress, neonatal asphyxia and neonatal hypoxic-ischemic encephalopathy in the monitoring group were significantly higher than those in the control group (P <0.05), and the cesarean section rate was also higher in the monitoring group than in the control group (P <0.01) ). Conclusion: The continuous increase of alpha-fetoprotein in pregnant women suggests that the fetus has intrauterine hypoxia, and it is necessary to improve the intrauterine environment and hypoxia in time. At the time of labor, we should relax the operation indications, terminate the pregnancy as soon as possible and treat the neonates promptly to reduce Poor perinatal outcomes.