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采用双抗体夹心法 EL ISA测定了 2 0例前列腺癌和 2 0例前列腺增生 (BPH)患者前列腺组织提取物中转化性生长因子 β2 (TGF- β2 )的含量。结果发现 :前列腺癌组织中的 TGF- β2 的含量 [(186 4.6± 5 6 6 .9) ng/ g]明显高于 BPH组 [(1318.7± 6 19.6 ) ng/ g],两个实验组 TGF- β2 含量比 8例正常对照 [(370 .8± 12 2 .6 ) ng/ g]高得多 ,差异具有显著性意义。提示 TGF- β2 不仅对前列腺的生理过程具有重要的生物学作用 ,而且可能参与 BPH和前列腺癌的发病过程。
The content of transforming growth factor β2 (TGF-β2) in prostate tissue extracts from 20 prostate cancer patients and 20 benign prostatic hyperplasia (BPH) patients was determined by double-antibody sandwich ELISA. The results showed that the content of TGF-β2 in prostate cancer tissue was significantly higher than that in BPH group [(186 ± 4.666) ng / g] [(1318.7 ± 6 19.6) ng / g] - β2 content was significantly higher than 8 normal controls [(370.8 ± 12.2.6) ng / g], the difference was significant. It is suggested that TGF-β2 not only plays an important biological role in the physiological process of prostate, but also may be involved in the pathogenesis of BPH and prostate cancer.