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目的 :探讨大剂量丙种球蛋白 (IVIG)在毛细支气管炎中的临床应用。方法 :将临床确诊的毛细支气管炎患儿 86例 ,按随机抽样法分对照组和大剂量IVIG组 ,大剂量IVIG组 ,每次IVIG 1 0g/kg ,连用 2天 ,观察疗效 ,病愈后对其随访。结果 :大剂量IVIG组的临床症状、吸氧时间、哮鸣音消失时间及住院时间与对照组比较有显著差异 (P <0 .0 1)。随访 76例 ,发生反复哮喘 ,大剂量IVIG组占 3 0 5 % ,对照组占 5 6 8% ,有显著性差异 (P <0 .0 1)。结论 :大剂量IVIG治疗毛细支气管炎急性期有明显疗效 ,并能减少病愈后反复哮喘发作。
Objective: To investigate the clinical application of high-dose gamma globulin (IVIG) in bronchiolitis. Methods: Eighty-six children with bronchiolitis diagnosed clinically were randomly divided into control group, high-dose IVIG group and high-dose IVIG group with IVIG 10g / kg for 2 days. The curative effect was observed. After recovery Follow up. Results: The clinical symptoms, oxygen inhalation time, disappearance time of wheeze and length of stay in high dose IVIG group were significantly different from those in control group (P <0.01). Follow-up 76 cases, repeated asthma, high-dose IVIG group accounted for 35%, control group accounted for 56.8%, a significant difference (P <0.01). Conclusion: The large dose of IVIG treatment of bronchiolitis acute phase has a significant effect, and can reduce the recurrence of asthma attacks after recovery.