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目的:观察醒髓汤(XST)对大鼠脊髓损伤后组织一氧化氮含量变化的影响,探讨XST在脊髓继发性损伤中的作用。方法:SD大鼠60只随机分组,改良的ALLEN’S法制成脊髓损伤模型,XST治疗7天,另设强的松龙对照组、模型组及空白组,观察伤后1h、8h、24h、3天、7天脊髓NO含量变化。结果:脊髓损伤后NO含量立即显著升高,至8h达到高峰,而后逐渐下降,醒髓汤组NO含量明显降低,与其它组相比差异有统计学意义(P<0.01)。结论:脊髓损伤后NO的升高是导致脊髓继发性损伤的重要因素,而醒髓汤能明显抑制脊髓损伤后组织NO含量的升高,改善脊髓损伤后的神经功能。
OBJECTIVE: To observe the effect of XingTong Decoction (XST) on the changes of tissue nitric oxide content after spinal cord injury in rats, and to explore the role of XST in secondary spinal cord injury. METHODS: Sixty SD rats were randomly divided into groups. The modified ALLEN’S method was used to make a spinal cord injury model. XST was used for 7 days. A prednisolone control group, a model group, and a blank group were set up to observe the 1h, 8h, 24h, and 3 days after injury. 7 days spinal cord NO content changes. RESULTS: After spinal cord injury, NO content increased immediately and reached a peak at 8h, then decreased gradually. The NO content in XingMing Decoction group was significantly lower than that in other groups (P<0.01). Conclusion: The increase of NO after spinal cord injury is an important factor in secondary injury of spinal cord, and Xingjie Decoction can obviously inhibit the increase of NO content in spinal cord after injury and improve the neurological function after spinal cord injury.