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流行性肾病(EN)是有肾脏综合征的出血热的一种类型。由Puumala病毒引起,并通过小啮齿动物的粪便进行传播。EN每年发病率均不同。每3-4年出现一次发病高峰。EN症状不典型,临床表现无特异性。临床中主要通过检测病人血中特异性Puumala病毒抗体而诊断。EN多发生于农村成人及森林工作者,儿童罕见。本文Lautala等对13例年龄16岁以下的EN病儿的临床和实验资料进行了回顾性分析。13例病儿中,8例根据特异性Puumala抗体确诊,其抗体滴度均升高≥4倍,或≥1∶160。另5例治疗前未检测抗体,临床诊断为EN。
Nephrotic nephropathy (EN) is a type of hemorrhagic fever with renal syndrome. It is caused by the Puumala virus and is transmitted by small rodent excrements. The annual incidence of EN is different. Every 3-4 years there peak incidence. EN symptoms are not typical, non-specific clinical manifestations. In clinic, it is mainly diagnosed by detecting the specific Puumala virus antibody in the patient’s blood. EN occurs mostly in rural adults and forest workers, children are rare. In this paper, Lautala et al retrospectively analyzed the clinical and experimental data of 13 children with EN under the age of 16 years. Of the 13 patients, 8 were diagnosed according to the specific Puumala antibody and their antibody titers were all increased by 4-fold or ≥1: 160. The other 5 cases before treatment did not detect antibodies, clinical diagnosis of EN.