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目的:观察乌司他丁对食管癌患者术后应激和炎症反应的影响。方法:选择我院2014年1月至2015年3月接受手术治疗的食管癌患者124例,随机分为两组,每组62例。观察组术后给予乌司他丁治疗,对照组仅接受常规抗感染治疗。观察并比较两组患者手术后应激反应和炎性因子的变化情况。结果:术后3d两组NE、E、Cor、TNF-α、IL-6、IL-8水平均较术前明显升高(P<0.05)。对照组NE、E、Cor、TNF-α、IL-6、IL-8水平升高幅度明显大于观察组,两组比较差异具有统计学意义(P<0.05)。观察组并发症发生率为8.06%,对照组并发症发生率为19.35%,两组并发症发生率比较差异具有统计学意义(P<0.05)。结论:食管癌患者行开胸切除术可引起全身炎症反应,乌司他丁的应用可抑制术后炎症因子的释放,减轻术后应激,对降低并发症的发生率,促进康复具有积极的作用。
Objective: To observe the effect of ulinastatin on postoperative stress and inflammatory response in patients with esophageal cancer. Methods: A total of 124 patients with esophageal cancer undergoing surgery from January 2014 to March 2015 in our hospital were randomly divided into two groups (62 in each group). The observation group was treated with ulinastatin, while the control group received only conventional anti-infective therapy. The changes of stress response and inflammatory factors after operation in both groups were observed and compared. Results: The levels of NE, E, Cor, TNF-α, IL-6 and IL-8 in the three groups after operation were significantly higher than those before operation (P <0.05). The levels of NE, E, Cor, TNF-α, IL-6 and IL-8 in the control group were significantly higher than those in the observation group. There was significant difference between the two groups (P <0.05). The complication rate in the observation group was 8.06%, while that in the control group was 19.35%. There was significant difference in the complication rates between the two groups (P <0.05). Conclusion: Thoracotomy in patients with esophageal cancer can cause systemic inflammatory response. The application of ulinastatin can inhibit the release of inflammatory cytokines and reduce the postoperative stress, which has a positive effect on reducing the incidence of complications and promoting rehabilitation effect.