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目的:探讨糖尿病病人单次晨尿白蛋白(ALb)浓度检测在诊断早期糖尿病肾病的临床意义及应用价值。方法:采用放射免疫法(RIA)测定32例非胰岛素依赖型糖尿病人(NIDDM)的晨尿ALb浓度,同时测白蛋白排泄率(UAE)作为对照。检测尿β_2微球蛋白(β_2—MG)及肌酐排泄率(Ccr),以判断晨尿ALb浓度与β_2—MG和Ccr之间的关系。结果:UAE升高组(早期糖尿病肾病组)的晨尿ALb浓度均较UAE正常组明显升高(P(0.01)与β_2—MG浓度正相关,与肌酐排泄率(Ccr)负相关。结论:晨尿ALb浓度升高可作为诊断早期糖尿病肾病的一项指标,它和UAE有相同的临床意义,并且更简单易行。
Objective: To investigate the clinical significance and application value of single morning urine albumin (ALb) concentration in the diagnosis of early diabetic nephropathy in diabetic patients. Methods: Radioimmunoassay (RIA) was used to determine the morning urine ALb concentration in 32 cases of non-insulin dependent diabetes mellitus (NIDDM). Meanwhile, the albumin excretion rate (UAE) was used as a control. Urinary β_2-microglobulin (β_2-MG) and creatinine excretion rate (Ccr) were measured to determine the relationship between morning urine ALb concentration and β_2-MG and Ccr. Results: The morning urine ALb concentration in UAE elevated group (early diabetic nephropathy group) was significantly higher than that in UAE normal group (P (0.01)) and β 2-MG concentration, and negatively correlated with creatinine excretion rate (Ccr) Morning urine ALb concentration can be used as an indicator of early diagnosis of diabetic nephropathy, it has the same clinical significance and UAE, and more simple and easy.