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目的:分析CD174在食管癌、胃癌、肠癌及其癌旁组织中的表达差异。方法:内窥镜取82例胃肠道肿瘤患者的活检组织,制成单细胞悬液后以流式细胞仪测定CD174表达情况。结果:肿瘤组织CD174的表达率低于癌旁组织,鳞癌中的表达率低于腺癌,低分化癌中的表达率低于高中分化癌,而印戒细胞癌CD174呈高表达率。结论:CD174在消化道肿瘤组织中的表达水平与正常组织存在差异,且其表达水平与肿瘤分化程度及病理类型等生物学特性之间存在着一定的相关性。
Objective: To analyze the expression of CD174 in esophageal cancer, gastric cancer, colorectal cancer and its adjacent tissues. Methods: Biopsies from 82 patients with gastrointestinal cancer were collected by endoscopy. The single cell suspension was used to determine the expression of CD174 by flow cytometry. Results: The expression of CD174 in tumor tissue was lower than that in paracancerous tissues. The positive rate of CD174 in squamous cell carcinoma was lower than that in adenocarcinoma. The positive rate of CD174 in poorly differentiated carcinoma was higher than that in high differentiated carcinoma. Conclusion: The expression level of CD174 in gastrointestinal tumor tissue is different from that in normal tissues. The expression level of CD174 is correlated with the biological characteristics such as tumor differentiation and pathological type.