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本文采用放射免疫分析法,对107例癫痫患者进行了149次血清苯妥英钠(DPH)测定,51例同时进行了血及唾液浓度测定。结果表明,DPH对控制发作的最适血清浓度为13.04±5.96 μg/ml(X±SD),唾液中DPH的有效浓度为1.34±0.67μg/ml,血清浓度约为唾液的10倍,血清浓度与唾液浓度成正相关,测定唾液浓度可代替血清浓度,直接反映游离药物水平,根据DPH浓度可进行药物剂量的调整,指导患者正确用药,对提高疗效有重要意义。
Radioimmunoassay was used in this study to measure the serum phenytoin sodium (DPH) in 107 epilepsy patients and the blood and saliva concentrations in 51 patients at the same time. The results showed that the optimal concentration of DPH for controlling seizure was 13.04 ± 5.96 μg / ml (X ± SD), the effective concentration of DPH in saliva was 1.34 ± 0.67 μg / ml, the serum concentration was about 10 times of saliva, the serum concentration And saliva concentration is positively related to the measurement of saliva concentration instead of serum concentration, a direct reflection of the level of free drugs, according to the concentration of DPH can be adjusted dose of drugs to guide patients with the correct medication, to improve the efficacy of great significance.