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本文报道给狗单剂量口服环孢素A片剂及口服液后体内血药浓度的高效液相色谱测定法及狗体内药代动力学和相对生物利用度研究的结果。使用3P87程序对药-时曲线进行处理，结果表明，环孢霉素A在狗体内的代谢符合一级吸收单室模型。片剂和口服液的主要药代动力学多数分别为t1／2ka为1．89±1．29h和1．33±1．55h，t1／2Kc＝937±2．23h和12．25±7．00h，tp＝4．43±4．08h和2．97±2．19h，Cmax＝608．71±154．99ng／ml和657．97±325．02ng／ml，环孢霉素A片剂对口服液的相对生物利用度为96．29％。
In this paper, high-performance liquid chromatography (HPLC) and in vivo pharmacokinetics and relative bioavailability of ciclosporin A tablet and oral solution to dogs were reported. The 3P87 program was used to process the drug-time curve. The results showed that the metabolism of cyclosporin A in dogs complied with the first-order absorption single-compartment model. The major pharmacokinetic profiles of tablets and oral solutions were t1 / 2ka of 1.89 ± 1.29h and 1.33 ± 1.55h, t1 / 2Kc = 937 ± 2.23h and 12.25 ± 7, respectively. 00h, tp = 4.43 ± 4.08 h and 2.97 ± 2.19 h, Cmax = 608.71 ± 154.99 ng / ml and 657.97 ± 325.02 ng / ml, cyclosporine A tablet pair The relative bioavailability of oral solution was 96.29%.