目的探讨浅表性膀胱癌患者行膀胱部分切除术或行TUR-Bt术后采用吡柔比星(THP)膀胱灌注预防肿瘤复发的疗效。方法 THP 40 g,每周1次,连用8周,而后每月1次,连用10个月,总疗程12个月。结果所有患者均获6～24个月的随访。平均随访18个月。复发11例,复发率19.6%。结论吡柔比星膀胱灌注预防浅表性膀胱癌术后复发的效果明确,疗效满意,不良反应少,是较为理想的膀胱灌注化疗药物。 Objective To investigate the curative effect of superficial bladder cancer patients undergoing bladder partial resection or TUR-Bt postoperative intravesical instillation of pirarubicin (THP) to prevent tumor recurrence. Method THP 40 g, once a week, once every 8 weeks, once a month, once every 10 months, the total course of 12 months. Results All patients were followed up for 6 to 24 months. The average follow-up of 18 months. Recurrence in 11 cases, the recurrence rate was 19.6%. Conclusion Intravesical instillation of pirarubicin is effective in preventing postoperative recurrence of superficial bladder cancer with satisfactory curative effect and less adverse reactions. It is an ideal intravesical chemotherapy for bladder infusion.